Studies on the mechanism of cortisone-induced metastases of transplantable mouse tumors.

During the course of investigations on the rela tive therapeutic effectiveness of various bacterial polysaccharide fractions on “metastatic― pul monary tumors induced by the intravenous injec tions of ascites tumor cells in Swiss mice and on the protective ability of cortisone and hydro cortisone in combating the toxicity of the bacterial products (16), it was noted that widespread blood borne metastases occurred with Krebs-II carci noma but not with Sarcoma 87 (Table 1). These